Representative Publications

REPRESENTATIVE PUBLICATIONS (* corresponding author)

  1. Lan Y, Sun J, Chen C, Wang H, Xiao Y, Perez M, Yang Y, Kwan YH, Sun YN, Zhou YD, Han XQ, Miyazaki J, Watsuji T, Bissessur D, Qian JW, Takai, Qian PY*. 2022. Endosymbiont population genomics sheds light on transmission mode, partner specificity, and stability of the scaly-foot snail holobiont. ISME J 16, 2132-2143.   1038/s41396-022-01261-4
  2. Qian PY*, Cheng AF, Wang RJ, Zhang R, 2022. Marine biofilms:diversity, interactions and biofouling. Nat Rev Microbiol.
  3. Tang JW, Liu X, Ye W, Li ZR, Qian PY*, 2022. Biosynthesis and bioactivities of microbial genotoxin colibactins. Nat Prod Rept 39, 991-1014. DOI: 10.1039/d1np00050k
  4. Xu T, Wang Y, Sun J, Chen C, Watanabe HK, Chen J, Qian PY*, Qiu JW*. 2021. Hidden historical habitat-linked population divergence and contemporary gene flow of a deep-sea patellogastropod limpet.  Mol Biol Evol 38 (12), 5640-5654.
  5. Zhou K, Xu Y, Zhang R, Qian PY*. 2021. Arm race in a cell: genomic, transcriptomic, and proteomic insights into intracellular phage-bacteria interplay in deep-sea snail holobionts.  Microbiome 9(1): 1-13.
  6. Sun YN, Sun J, Yang Y, Lan Y, Ip JCH, WC Wong, Kwan YK, YJ Zhang, Han Z, Qiu JW*, Qian PY*. 2021.  Genomic signatures supporting the symbiosis and formation of chitinous tube in the deep-sea tubeworm Paraescarpia echinospicaMol Biol Evol 38 (10): 4116-4134.
  7. Geng Y, Liu C, Cai Q, Luo Z, Miao H, Shi X, Xu N, Fung CP, Choy TT,Yan B, Li N, Qian PY*, Zhou B*, Zhu G.* Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence, Nuc Aci Res 49 (10): 5881-5890.
  8. Li, ZR, Sun J, Du YL, Pan AF, Zeng L, Maboundian R, Burne RA, Qian PY*, Zhang WJ*. Mutanofactin promotes bacterial adhesion and biofilm formation of cariogenic Streptococcus mutans.  Nature Chem Biol
  9. Lan Y, Sun J, Chen C, Sun YN, Zhou YD, Yang Y, Zhang WP, Li RS, Zhou K, Wong WC, Kwan YH, Cheng AF, Bougouffa S, van Dover CL, Qiu JW, Qian PY*. 2021. Dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis revealed by its hologenome. Nature Communication 12: 1165.
  10. Malit JJL, Liu WC, Cheng AF, Saha S, Liu LL, Qian PY*. Global genome minining reveals a cytochrome P450-catalyzed cyclization of crownlike cyclodipeptides with neuroprotective activity. Org Lett 23, 6601-6605.
  11. Yang Y, Sun J, Sun YN, Kwan YH, Wong WC, Zhang YJ, Xu T, Feng D, Zhang Y, Qiu JW, Qian PY*. 2020. Genomic, transcriptomic and proteomic insights into the symbiosis of deep-sea tubeworm holobionts. ISME J 14: 135-150. org/10.1038/s41396-019-0520-y
  12. Nong WY, Cao JQ, Li YQ, Qu Z, Sun J, Swale T, Yip HY, Qian PY, Qiu JW, Kwan HS, Bendena W, Tobe S, Chan TF, Yip KYL, Chu KH, Ngai SM, Tsim KYK, Holland PWH, Hui JHL. Jellyfish genomes reveal distinct homeobox gene clusters and conservation of small RNA processing. Nature Communication 113051
  13. Zhang WJ*, Qian PY*. Reply to: Macrocyclic colibactins. Nat Chem. 12(11): 1007-1007.
  14. Sun J, Chen C, Miyamoto N, Li RS, Sigwart JD, Xu T, Sun YN, Wong WC, Ip JCH, Zhang WP, Lan Y, Bissessur D, Watsuji T, Watanabe HK, Takaki Y, Qiu JW, Takai K*, Qian PY*. The Scaly-foot Snail genome and the ancient origins of biomineralised armour. Nature Communication 11: 1657.
  15. Li ZR, Li J, Cai WL, Lai JYH, Zhang WP, McKinnie SMK, Moore BS, Zhang WJ*, Qian PY*. Colibactin induces DNA double-strand breaks through copper-dependent oxidative cleavage.  Nature Chemistry 11(10):880-889.
  16. Zhang WP, Ding W, Li YX, Tam CK, Bougouffa S, Wang RJ, Pei B, Chiang HY, Leung PM , Lu YH, Sun J, Fu H, Bajic VB, Liu HB, Webster NS, Qian PY*, 2019. Biofilms constitute a bank of hidden microbial diversity and functional potential in the oceans, Nature Communication 10: 517 |
  17. Sun J, Mu HW, Ip JCH, Li RS, Zhang YJ, Xu T, Kumagai N, Yusa Y, Accorsi A, Castro-Vasquez A, Vega IA, Heras H, Ituarte S, Bocxlaer BV, Hayes K, Cowie R, Zhao ZY, Zhang Y*, Qian PY*, Qiu JW*. Signatures of divergence, invasiveness, and terrestrialization revealed by four apple snail genomes.    Mol Biol Evol 36: 1507-1520.  Doi:10.1093/molbev/msz084.
  18. Li YX, Zhong Z, Zhang WP, Qian PY*. 2018. Discovery of cationic nonribosomal peptides as gram-negative antibiotics through global genome mining. Nat Communi 9: 3273, 1038/s41467-018-05781-6.
  19. Li YX, Zhong Z, Hou P, Zhang WP, Qian PY*. A widespread D-stereospecific resistance of nonribosomal peptide antibiotics. Nat Chem Biol 14: 381-388,
  20. Sun J, Zhang Y, Xu T, Zhang Y, Mu HW, Zhang YJ, Lan Y, Fields CJ, Hui JHL, Zhang WP, Li RS, Nong WY, Cheung FKM, Qiu JW*, Qian P-Y*. 2017. Adaptation to deep-sea chemosynthetic environments as revealed by mussel genomes.  Nat Ecol Evol 1: 0121 .
  21. Lin JS, Zhang WP, Cheng JL, Yang X, Zhu KX, Wang Y, Wei GH, Qian PY, Luo ZQ. 2017. A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition.  Nat Comms. 8:  
  22. Li ZR, Li J, Gu JP, Lai JY, Duggan BM, Zhang W, Li ZL, Li YX, Tong RB, Xu Y, Lin DH, Moore B, Qian PY*. (2016) Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nat Chemical Biology 12, 773–778.
  23. Zhang WP, Sun J, Cao HL, Tian RM, Cai L, Ding W, Qian P-Y*. 2016. Post-translational modifications are enriched within protein functional groups important to bacterial adaptation within a deep-sea hydrothermal vent environment.  Microbiome 4: 49. DOI: 1186/s40168-016-0194-x
  24. Ross AC, Xu Y (co-first author), Lu L, Kersten RD, Shao ZZ, Al-Suwailem AM, Dorrestein PC, Qian PY*, Moore BS*. 2013. Biosynthetic multitasking facilitates thalassospiromide structural diversity in marine bacteria.    JACS 135: 1155 
  25. Xu Y, Kersten RD, Nam SJ, Lu L, Al-Suwailem AM, Zheng HJ, Fenical W, Dorrestein PC, Moore BS, Qian PY*. Bacterial biosynthesis and maturation of the didemnin anticancer agents.  JACS 134: 8625-8632.
  26. Wang Y, Yang JK, Lee OO, Dash S, Lau SCK, Al-Suwailem A, Wong TYH, Danchin A, Qian PY*, 2011. Hydrothermally generated aromatic compounds are consumed by bacteria colonizing in Atlantis II Deep of the Red Sea.   ISME J 5: 1652-1659. DOI: 1038/ismej.2011.42
  27. Lee OO, Wang Y, Yang JK, Lafi F, Al-Suwailem A, Qian PY*. Pyrosequencing reveals highly diverse and species-specific microbial communities in sponges from the Red Sea.  ISEM J 5: 650-664. 
  28. Qian PY*, Wang Y, Lee OO, Lau SCK, Yang JK, Lafi FF, Al-Suwailem A, Wong T. Vertical stratification of microbial communities in the Red Sea revealed by pyrosequencing.  ISEM J 5: 507-518.
  29. Chung HC, Lee OO, Huang YL, Mok FY, Kolter R, Qian PY*. Bacterial community succession and chemical profile of subtidal biofilms in relation to larval settlement of the polychaete Hydroides elegansISME J 4: 817-828.
  30. Huang YL, Ki JS, Lee OO, Qian PY*.    Evidence for the dynamics of acyl homoserine lactone based quorum sensing during early subtidal biofilm formation.  ISME J 3: 296-304 (Nature group).

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